Read on to learn about how spironolactone can be a treatment for acne in women and its side effects. Spironolactone (Aldactone) is used for treating acne, hair loss, high blood pressure, heart failure, and a condition called primary hyperaldosteronism. Find a comprehensive guide to possible side effects including common and rare side effects when taking Aldactone (Spironolactone) for healthcare professionals and consumers. But even as my hormonal acne worsened, I never even entertained the idea of going on Accutane—and even spironolactone, Accutane's relatively unknown cousin of sorts. SIDE EFFECTS: Drowsiness, dizziness, lightheadedness, stomach upset, diarrhea, nausea, vomiting, or headache may occur. To minimize lightheadedness, get up slowly when rising from a seated or lying position. Learn about the potential side effects of Aldactone (spironolactone). Includes common and rare side effects information for consumers and healthcare professionals. Includes common and rare side effects information for consumers and healthcare professionals. Tell your doctor if you have serious side effects of Aldactone including irregular heart rate, muscle pain or weakness, urinating less than usual, shallow breathing, tremors, confusion, or a severe skin reaction, hyperkalemia (high levels of potassium in the blood), and numbness. Aldactone (spironolactone) is a prescription diuretic used to remove the excess fluid caused by congestive heart failure, cirrhosis of the liver, and kidney disease. Serious side effects include kidney failure, liver dysfunction, vasculitis, and low platelets. Drug interactions, dosage, and pregnancy and breastfeeding information are provided. Spironolactone (Aldactone) is used for treating acne, hair loss, high blood pressure, heart failure, and a condition called primary hyperaldosteronism. Spironolactone (Aldactone) - Side Effects. Find information about common, infrequent and rare side effects of Spironolactone Oral. Aldactone (spironolactone) is used to diagnose or treat a condition in which you have too much aldosterone in your body. Includes Aldactone side effects, interactions and indications. Aldactone is only effective against acne caused by hormonal fluctuations, for example women who consistently break out around the time of their monthly cycle. It's especially helpful for women with hormonal disorders that trigger acne, or who have acne along with other problems like unwanted facial hair.